Melatonin drops from Soria Natural is a food supplement of 100% pure melatonin (1.8 mg). Melatonin contributes to the reduction of the time needed to fall asleep and the relief of the subjective sensation of jet lag. Melatonin (N-acetyl-5-methoxytryptamine) is a hormone produced in the brain by the pineal gland, as well as in other tissues, from the neurotransmitter serotonin. The synthesis and release of melatonin are stimulated by darkness and suppressed by natural or artificial light. When night falls and the eye no longer perceives daylight, the retina sends stimuli through the nerve pathway that reach the suprachiasmatic nucleus of the hypothalamus, which, in turn, sends signals to the pineal gland, initiating the synthesis and release of melatonin. The highest concentrations are reached during periods of maximum darkness, in the middle of the night, and gradually decrease until morning, remaining very low throughout the day. Melatonin plays multiple important roles in the body, coordinating and regulating biological rhythms (chronobiotic capacity), as well as various cellular, neuroendocrine, and neuroimmune processes. • It plays a crucial role in regulating the sleep-wake cycle and facilitates sleep onset and consolidation. Although these effects are primarily due to melatonin's action on the suprachiasmatic nucleus, the main center for regulating biological rhythms, an effect on cardiovascular and thermoregulatory centers has also been observed. • Antioxidant : Melatonin is a potent antioxidant. It works directly to neutralize free radicals from oxygen and nitrogen (hydrogen peroxide, singlet oxygen, peroxynitrite anion) and indirectly by activating other antioxidant enzymes such as glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase, and by enhancing the action of other antioxidants such as vitamins C and E and glutathione. • Immune system : helps innate immunity (stimulates the activity of macrophages, neutrophils and NK cells, modulates the production of cytokines), and with adaptive immunity (increases T and B lymphocytes and modulates humoral and cellular responses by regulating mediators such as IL-2 and 5-lipoxygenase). • Anti-aging : action related to antioxidant, immunomodulatory activity and reduction of swelling. • Other functions : helps regulate blood pressure, temperature, nutritional status, metabolism, and digestive function. *The packaging received may be slightly different from the image on the product sheet. It is recommended to take 10 drops (0.5 ml) a day, half an hour before going to bed. Recommended from 3 years. Under three years according to optional criteria. The beneficial effect is obtained with an intake of 1 mg of melatonin shortly before going to sleep. Take at bedtime on the first day of travel and a few days after arrival at destination. Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. A varied and balanced diet and a healthy lifestyle are important. It should not be consumed in case of sensitivity to any of its components Avoid exceeding the recommended daily dose. Keep out of reach of children. Store in a cool, dry place, protected from sunlight.