Methyl Folate 400mcg increases stability and bioavailability. It is a highly biologically active form of folate. Quatrefolic is the 4th generation development in folate delivery. A Highly Bioactive Form Of Folate. Quatrefolic®. Increased Stability & Bioavailability. Extra Strength, 400mcg of Folate per serving. Due to the body's limited ability – in addition to physiological stresses and individual variability – to transform synthetic folic acid into the active form of folate (which can lead to the accumulation of unmetabolized folic acid in the body and may interfere with the transport and metabolism of natural folates), supplementation with 5-MTHF is highly preferable. Unlike folic acid, 5-MTHF can cross the blood-brain barrier and does not mask pernicious anemia. Healthful diets with adequate folate may reduce the risk of having a child with a brain or spinal cord defect. Adults take 1 capsule once a day with or without food or as directed by your qualified healthcare professional. Food supplements should not be used as a substitute for a balanced and varied diet and a healthy lifestyle. Do not exceed the recommended daily dose. Keep out of reach of young children. Store in a cool, dry place.